Abruzzo, Molise, and Le Marche all comprise the middle of Italy's Adriatic (Eastern) coast. Each offers its own culture, cuisine, and natural beauty.
A mountanous region just northeast of Lazio, contains the charming city of L'Aquila (which was hit by an earthquake and hosted the G8 in 2009) and the beautiful Gran Sasso National Park (the highest point in Italy outside of the Alps).
Molise has similar scenery and climate to Abruzzo and is the site of the San Vincenzo Abbey service project.
Also referred to as "Marches", Le Marche is named after the historic March of Ancona, and is actually quite hilly. Just east of Tuscany and Umbria, it features some excellent hill towns, like its neighbors, but few of the crowds.